HCID 14654393, 화합물 → cis-Azetidine-2,4-dicarboxylic acid
반응식
C([O:8][C:9]([C@H:11]1[CH2:14][C@@H:13]([C:15]([O:17]CC2C=CC=CC=2)=[O:16])[N:12]1CC1C=CC=CC=1)=[O:10])C1C=CC=CC=1>CO.O.[Pd]>[NH:12]1[C@H:13]([C:15]([OH:17])=[O:16])[CH2:14][C@@H:11]1[C:9]([OH:10])=[O:8]참가 물질
5
실험 절차
208 mg (0.5 mmol) of stereochemically pure transor cis-N-benzylazetidine-2,4-dicarboxylic acid dibenzyl ester and 20 mg of 10% Pd/C in 15 ml of methanol are hydrogenated as above. The reaction mixture is diluted with 50 ml of warm water, filtered, and evaporated to dryness to afford as off-white solids the trans- or cis azetidine-2,4-dicarboxylic acid in virtually quantitative yield.
후처리
- filtrationfiltered
- customevaporated to dryness
출처 및 근거
- ORD 기록
- ord-64472fa02f594f64b05a762d3fbb4a40
- 출처 데이터셋
- uspto-grants-1991_02
- 특허 번호
- US04990504
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