Imidazo(4,5-b)pyridine → N,N-dicyclopentyl-6-(5H-imidazo[4,5-c]pyridin-5-yl-methyl)-3-pyridinecarboxamide

HRID 981056

반응식

HRID 981056 반응식
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[N:9][C:4]=2[N:3]=[CH:2]1.Cl[CH2:11][C:12]1[CH:30]=[CH:29][C:15]([C:16]([N:18]([CH:24]2[CH2:28][CH2:27][CH2:26][CH2:25]2)[CH:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[O:17])=[CH:14][N:13]=1>CC(N(C)C)=O>[CH:24]1([N:18]([CH:19]2[CH2:20][CH2:21][CH2:22][CH2:23]2)[C:16]([C:15]2[CH:14]=[N:13][C:12]([CH2:11][N:9]3[CH:8]=[CH:7][C:6]4=[N:3][CH:2]=[N:1][C:5]4=[CH:4]3)=[CH:30][CH:29]=2)=[O:17])[CH2:28][CH2:27][CH2:26][CH2:25]1

참가 물질

4

반응물 2

HCID 67504Imidazo(4,5-b)pyridineHCID 200716396-Chloromethyl-N,N-dicyclopentylnicotinamide

생성물 1

HCID 20071631N,N-dicyclopentyl-6-(5H-imidazo[4,5-c]pyridin-5-yl-methyl)-3-pyridinecarboxamide

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

To a stirred solution of imidazopyridine (540 mg, 4.5 mmol) in dimethylacetamide (100 mL) under argon, the product of Example D (1.6 g,) was added in one portion. The reaction temperature was slowly raised to 80°-85° C. and was stirred for 60 h. The reaction flask was cooled to room temperature and the solvent was removed under reduced pressure at <45° C. The residue obtained was triturated with excess of dry ether and filtered.

후처리

  1. temperatureThe reaction temperature was slowly raised to 80°-85° C.
  2. customthe solvent was removed under reduced pressure at <45° C
  3. customThe residue obtained
  4. customwas triturated with excess of dry ether
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-8648edcbe1ae4444a0dfefa027ae35e3
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04990518

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