Phenethylamine → trans-1-Benzyl-3-benzylmethylamino-4-hydroxypyrrolidine

HRID 981096노트

반응식

HRID 981096 반응식
[CH2:1]([N:8]1[CH2:13][CH:12]2[CH:10]([O:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:14]([CH2:21][NH2:22])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>O1CCOCC1.O>[CH2:1]([N:8]1[CH2:9][C@@H:10]([OH:11])[C@H:12]([NH:22][CH2:21][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 1001PhenethylamineHCID 98153703-Benzyl-6-oxa-3-azabicyclo(3.1.0)hexane

생성물 1

HCID 69706831trans-1-Benzyl-3-benzylmethylamino-4-hydroxypyrrolidine

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

19.4 g (0.1 mol) of 90% strength 3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane are heated under reflux with 14.5 g (0.12 mol) of benzylmethylamine in 100 ml of dioxane and 200 ml of water overnight. The mixture is extracted with CHCl3, the extracts are dried with K2CO3 and concentrated and the residue is subjected to incipient distillation up to 160° C. (oil bath temperature).

후처리

  1. extractionThe mixture is extracted with CHCl3
  2. dry with materialthe extracts are dried with K2CO3
  3. concentrationconcentrated
  4. distillationdistillation up to 160° C. (oil bath temperature)

출처 및 근거

ORD 기록
ord-7f933b2324e345e2805468a76c4927de
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04990517

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