Ethyl 3-(hydroxymethyl)-4-(methylamino)pyrrolidine-1-carboxylate → (4-(Methylamino)pyrrolidin-3-yl)methanol
반응식
[OH:1][CH2:2][CH:3]1[CH2:7][N:6](C(OCC)=O)[CH2:5][CH:4]1[NH:13][CH3:14]>O>[OH:1][CH2:2][CH:3]1[CH2:7][NH:6][CH2:5][CH:4]1[NH:13][CH3:14]참가 물질
3
실험 절차
34 g (0.168 mol) of ethyl 4-hydroxymethyl-3-methylaminopyrrolidine-1-carboxylate are heated under reflux with 100 g of Ba(OH)2.8H2O in 400 ml of water overnight. The BaCO3 is filtered off with suction, the filtrate is concentrated and the residue is boiled up ten times with 100 ml of dioxane each time. The dioxane solutions are filtered, the filtrate is concentrated and the residue is distilled.
후처리
- filtrationThe BaCO3 is filtered off with suction
- concentrationthe filtrate is concentrated
- filtrationThe dioxane solutions are filtered
- concentrationthe filtrate is concentrated
- distillationthe residue is distilled
출처 및 근거
- ORD 기록
- ord-bab319d9d25742f289722319af7d1b8d
- 출처 데이터셋
- uspto-grants-1991_02
- 특허 번호
- US04990517
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