Ethyl trans-4-azido-3-methoxy-1-piperidinecarboxylate → Ethyl trans-4-amino-3-methoxy-1-piperidinecarboxylate
반응식
[N:1]([C@@H:4]1[CH2:9][CH2:8][N:7]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:6][C@H:5]1[O:15][CH3:16])=[N+]=[N-].[H][H]>[Pd].CO>[NH2:1][C@@H:4]1[CH2:9][CH2:8][N:7]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:6][C@H:5]1[O:15][CH3:16]참가 물질
5
실험 절차
A mixture of 15.6 parts of ethyl trans-4-azido-3-methoxy-1-piperidinecarboxylate and 200 parts of methanol was hydrogenated at normal pressure and at room temperature with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated in vacuo, yielding 13.8 parts (97.4%) of ethyl trans-4-amino-3-methoxy-1-piperidinecarboxylate as a residue (interm. 5).
후처리
- filtrationthe catalyst was filtered off
- customthe filtrate was evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-afed1b3cc59e414a9f5917e0bd69902c
- 출처 데이터셋
- uspto-grants-1991_02
- 특허 번호
- US04990521
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