Ammonia → 1-(6-Amino-5-chloropyridin-3-YL)ethan-1-one

HRID 981323노트

반응식

HRID 981323 반응식
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9](=[O:11])[CH3:10])=[CH:4][N:3]=1.[NH3:12]>O1CCCC1>[NH2:12][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9](=[O:11])[CH3:10])=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 101980061-(5,6-Dichloropyridin-3-yl)ethan-1-one

생성물 1

HCID 143713831-(6-Amino-5-chloropyridin-3-YL)ethan-1-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1.9 g (10 mmol) of 2,3-dichloro-5-acetylpyridine are heated at 170° C. in a mixture of 80 ml of tetrahydrofuran and 20 ml of concentrated aqueous ammonia in an autoclave for 8 hours. After the tetrahydrofuran has been evaporated off, the residue is diluted with water and the mixture is brought to pH 5 and extracted with ethyl acetate.

후처리

  1. customAfter the tetrahydrofuran has been evaporated off
  2. additionthe residue is diluted with water
  3. extractionextracted with ethyl acetate

출처 및 근거

ORD 기록
ord-2a33f0ffef99423ca305976b52ddcdf5
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04990620

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