Thionyl Chloride → Benzoyl chloride, 2,4-dichloro-5-fluoro-3-nitro-

HRID 981361

반응식

HRID 981361 반응식
[Cl:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[C:9]([Cl:14])[C:8]([F:15])=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:18])=O>CN(C)C=O>[Cl:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[C:9]([Cl:14])[C:8]([F:15])=[CH:7][C:3]=1[C:4]([Cl:18])=[O:5]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 27342592,4-Dichloro-5-fluoro-3-nitrobenzoic acid

생성물 1

HCID 11818130Benzoyl chloride, 2,4-dichloro-5-fluoro-3-nitro-

시약·촉매·용매 1

HCID 6228Dimethylformamide촉매

실험 절차

254 g (1 mol) of 2,4-dichloro-5-fluoro-3-nitro-benzoic acid are refluxed in 700 ml of thionyl chloride with addition of 3 drops of dimethylformamide until the gas evolution ceases. Excess thionyl chloride is removed by distillation, and the residue is fractionated in vacuo.

후처리

  1. customExcess thionyl chloride is removed by distillation

출처 및 근거

ORD 기록
ord-6e9702b552f34a4487227e7863837c8d
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04990661

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