Dicyclohexylcarbodiimide → 2,4-Dimethyl-4-isopropyl-2-oxazolin-5-one

HRID 981436노트

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HRID 981436 반응식
[C:1]([NH:4][C:5]([CH3:12])([CH:9]([CH3:11])[CH3:10])[C:6]([OH:8])=[O:7])(=O)[CH3:2].C1(N=C=NC2CCCCC2)CCCCC1>C1COCC1>[CH3:2][C:1]1[O:7][C:6](=[O:8])[C:5]([CH3:12])([CH:9]([CH3:11])[CH3:10])[N:4]=1

참가 물질

4

반응물 2

HCID 10868DicyclohexylcarbodiimideHCID 2338052-Acetamido-2,3-dimethylbutanoic acid

생성물 1

HCID 146957652,4-Dimethyl-4-isopropyl-2-oxazolin-5-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
25 °C

실험 절차

2-Acetamido-2,3-dimethylbutyric acid (16 g) is dissolved in THF (200 mL) and dicyclohexylcarbodiimide (DCC, 21.0 g) is added. The mixture is allowed to stir for 16 hours at 25° C. At the end of this time the mixture is filtered and evaporated to dryness. The residue is dissolved in CH2Cl2 (10 mL) and filtered again. Evaporation of the filtrate gives the crude product which is purified by distillation at 0.65 mmHg, having bp 50° C.

후처리

  1. filtrationAt the end of this time the mixture is filtered
  2. customevaporated to dryness
  3. dissolutionThe residue is dissolved in CH2Cl2 (10 mL)
  4. filtrationfiltered again
  5. customEvaporation of the filtrate

출처 및 근거

ORD 기록
ord-9b49f7beb86d42ccb7cc40b50b316e68
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04992094

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