4-Fluorobenzoyl chloride → N-Methylbenzamide
반응식
FC1C=CC(CNC)=CC=1.F[C:12]1[CH:21]=[CH:20][C:15]([C:16]([NH:18][CH3:19])=[O:17])=[CH:14][CH:13]=1.FC1C=CC(C(Cl)=O)=CC=1>CN>[CH3:19][NH:18][C:16](=[O:17])[C:15]1[CH:20]=[CH:21][CH:12]=[CH:13][CH:14]=1참가 물질
5
실험 절차
This compound was prepared from 4-Fluoro-N-methylbenzylamine which in turn was prepared from 4-Fluoro-N-methylbenzamide. Practical details are as follows: 4-Fluorobenzoyl chloride (25g) was added dropwise to a stirred aqueous solution of methylamine (40% w/v; 250 ml) at 0° C. over 30 min. The mixture was stirred for 12 h at room temperature, concentrated to half volume and the resulting crystalline precipitate was collected and recrystallized from water to furnish the N-methylbenzamide as colourless needles, (24.1 g; 89.1%), m.p. 131°-132° C.
후처리
- concentrationconcentrated to half volume
- customthe resulting crystalline precipitate was collected
- customrecrystallized from water
출처 및 근거
- ORD 기록
- ord-afdb13066def4d9cbbc7a209980b998e
- 출처 데이터셋
- uspto-grants-1991_02
- 특허 번호
- US04992444
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