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Water → 3-(4-Fluorophenyl)-5-isopropyl-1,2-diphenylpyrrole

HRID 981588
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HRID 981588 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:17][C:18](=O)[CH:19]([CH3:21])[CH3:20])[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=O)=[CH:4][CH:3]=1.[NH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1.C(OCC)(=O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:17]=[C:18]([CH:19]([CH3:21])[CH3:20])[N:23]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:9]=2[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 6115AnilineHCID 143002712-(4-Fluorophenyl)-5-methyl-1-phenylhexane-1,4-dione

생성물 1

HCID 144613403-(4-Fluorophenyl)-5-isopropyl-1,2-diphenylpyrrole

시약·촉매·용매 2

HCID 1140Toluene용매
HCID 8857
Ethyl Acetate
용매

실험 절차

10.1 g (34 mmol) of 2-(4-fluorophenyl)-5-methyl-1-phenyl-hexane-1,4-dione (Example 2) and 9.3 mmol (102 mmol) of aniline in 150 ml of toluene are heated under reflux in a water separator for 24 hours with the addition of 500 mg of p-toluenesulphonic acid. After cooling and diluting with ethyl acetate, the reaction mixture is washed with 1 N hydrochloric acid and then with sodium bicarbonate solution, dried over magnesium sulphate and concentrated in vacuo. The residue is then chromatographed on silica gel.

후처리

  1. temperatureAfter cooling
  2. washthe reaction mixture is washed with 1 N hydrochloric acid
  3. dry with materialwith sodium bicarbonate solution, dried over magnesium sulphate
  4. concentrationconcentrated in vacuo
  5. customThe residue is then chromatographed on silica gel

출처 및 근거

ORD 기록
ord-17b23d844ecc492c8f3c954c774dbf54
출처 데이터셋
uspto-grants-1991_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04992462

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