1-[3-[4-(4,5-Dihydro-2-oxazolyl)phenoxy]propyl]-4-(phenylmethyl)piperazine → 1-[3-[4-(4,5-Dihydro-2-oxazolyl)phenoxy]propyl]piperazine

HRID 981608노트

반응식

HRID 981608 반응식
[O:1]1[CH2:5][CH2:4][N:3]=[C:2]1[C:6]1[CH:28]=[CH:27][C:9]([O:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][N:17](CC3C=CC=CC=3)[CH2:16][CH2:15]2)=[CH:8][CH:7]=1.[H][H]>[Pd].CO>[O:1]1[CH2:5][CH2:4][N:3]=[C:2]1[C:6]1[CH:7]=[CH:8][C:9]([O:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)=[CH:27][CH:28]=1

참가 물질

5

반응물 2

HCID 149891781-[3-[4-(4,5-Dihydro-2-oxazolyl)phenoxy]propyl]-4-(phenylmethyl)piperazineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 149891791-[3-[4-(4,5-Dihydro-2-oxazolyl)phenoxy]propyl]piperazine수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 56 parts of 1-[3-[4-(4,5-dihydro-2-oxazolyl)phenoxy]propyl]-4-(phenylmethyl)piperazine and 480 parts of methanol was hydrogenated at normal pressure and at 50° C. with 5 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was taken up in water and the product was extracted with dichloromethane. The extract was dried, filtered and evaporated, yielding 46.9 parts (100%) of 1-[3-[4-(4,5-dihydro-2-oxazolyl)phenoxy]propyl]piperazine as a residue (int. 16).

후처리

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated
  3. extractionthe product was extracted with dichloromethane
  4. customThe extract was dried
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-15b225ec6f5347889ed51ed2d6188d38
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04992433

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