Sodium Methoxide → 3,3-Dimethyl-2-methoxy-2-(4-piperidinophenyl)-oxirane

HRID 981755노트

반응식

HRID 981755 반응식
Br[C:2]([CH3:18])([CH3:17])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:7][CH:6]=1)=[O:4].[CH3:19][O-:20].[Na+]>CO>[CH3:17][C:2]1([CH3:18])[O:4][C:3]1([O:20][CH3:19])[C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 198795192-Bromo-2-methyl-1-(4-piperidinophenyl)-propan-1-one

생성물 1

HCID 198794483,3-Dimethyl-2-methoxy-2-(4-piperidinophenyl)-oxirane

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

12.0 g (38.7 mmol) of 2-bromo-2-methyl-1-(4-piperidinophenyl)-propan-1-one are dissolved in 20 ml of methanol, and 7.0 g (46.4 mmol) of methanolic 30% strength sodium methylate solution are then added dropwise at room temperature. The methanol is then distilled off under reduced pressure. The residue is taken up in toluene, and the precipitated salt is filtered off. The solution is concentrated in vacuo. The brown residue, which is a slowly crystallising liquid, is directly further reacted.

후처리

  1. distillationThe methanol is then distilled off under reduced pressure
  2. filtrationthe precipitated salt is filtered off
  3. concentrationThe solution is concentrated in vacuo
  4. customa slowly crystallising liquid

출처 및 근거

ORD 기록
ord-90203538269948f387bb4e179d3eab97
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04992547

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