Dichloromethane → HCID 67926768, 화합물

HRID 981766노트

반응식

HRID 981766 반응식
[CH3:1][O:2][C:3](=[O:10])[CH:4]([CH2:6][C:7]([OH:9])=[O:8])[OH:5].C(OC(=NC(C)C)NC(C)C)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[CH2:28](Cl)Cl>CN(C=O)C>[CH3:28][O:8][C:7](=[O:9])[CH2:6][CH:4]([OH:5])[C:3]([O:2][CH2:1][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:10]

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 11128254o-Benzyl-n,n'-diisopropylisoureaHCID 121005551-Methyl malate

생성물 1

HCID 67926768HCID 67926768, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Malic acid monomethyl ester (Example 2A) was dissolved in DMF and one equivalent of O-benzyl-N,N'-diisopropylisourea was added. The reaction mixture was stirred at room temperature for about 17 hours. Methylene chloride was added to the mixture and the suspension was filtered to remove the diisopropylurea. The filtrate was further diluted with methylene chloride and washed with water, 10% aqueous sodium carbonate, water, and with brine and was dried over magnesium sulfate. After filtration and evaporation the monobenzyl monomethyl ester was obtained as an oil.

후처리

  1. filtrationthe suspension was filtered
  2. customto remove the diisopropylurea
  3. additionThe filtrate was further diluted with methylene chloride
  4. washwashed with water, 10% aqueous sodium carbonate, water
  5. dry with materialwith brine and was dried over magnesium sulfate
  6. filtrationAfter filtration and evaporation the monobenzyl monomethyl ester
  7. customwas obtained as an oil

출처 및 근거

ORD 기록
ord-4386ffe2627e4225bdb58f6ef0a8da7e
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04992544

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