Ethylamine → HCID 10334355, 화합물

HRID 981909노트

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HRID 981909 반응식
[CH2:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8](Cl)=[C:7]([N+:16]([O-:18])=[O:17])[C:6]1=[O:19])[CH2:2][CH2:3][CH3:4].[CH2:20]([NH2:22])[CH3:21]>O1CCCC1>[CH2:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([NH:22][CH2:20][CH3:21])=[C:7]([N+:16]([O-:18])=[O:17])[C:6]1=[O:19])[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 2

HCID 6341EthylamineHCID 99709251-Butyl-4-chloro-3-nitroquinolin-2(1H)-one

생성물 1

HCID 10334355HCID 10334355, 화합물수율 97%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

3.5 g (0.013 mole) of Compound d in Reference Example 4 was dissolved in 30 ml of tetrahydrofuran, and 8.0 ml (0.13 mole) of ethylamine was added with ice cooling, followed by stirring at room temperature overnight. The solvent was evaporated under reduced pressure and ice water was added to the residue. The precipitate was collected by filtration and dried, to afford 3.5 g of Compound e (97%).

후처리

  1. customThe solvent was evaporated under reduced pressure and ice water
  2. additionwas added to the residue
  3. filtrationThe precipitate was collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-0a6203f950c24f5d95988075bf034413
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04994468

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