Methylamine → 2(1H)-Quinolinone, 1-butyl-4-(methylamino)-3-nitro-

HRID 981910노트

반응식

HRID 981910 반응식
[CH2:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8](Cl)=[C:7]([N+:16]([O-:18])=[O:17])[C:6]1=[O:19])[CH2:2][CH2:3][CH3:4].[CH3:20][NH2:21]>O1CCCC1>[CH2:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([NH:21][CH3:20])=[C:7]([N+:16]([O-:18])=[O:17])[C:6]1=[O:19])[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 99709251-Butyl-4-chloro-3-nitroquinolin-2(1H)-one

생성물 1

HCID 100847802(1H)-Quinolinone, 1-butyl-4-(methylamino)-3-nitro-수율 87%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

11 g (0.039 mole) of Compound d obtained in Reference Example 4 was dissolved in 100 ml of tetrahydrofuran, and 30 ml (0.39 mole) of 40% methylamine was added with ice cooling, followed by stirring at room temperature for one hour. Then, the solvent was evaporated under reduced pressure, and water was added to the residues. The precipitate was collected by filtration and dried, to afford 9.2 g of Compound w (yield: 87%).

후처리

  1. customThen, the solvent was evaporated under reduced pressure, and water
  2. additionwas added to the residues
  3. filtrationThe precipitate was collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-f3f84304477a4b1daecbafdedaab4c43
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04994468

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