Ammonium Chloride → HCID 9795016, 화합물

HRID 981922노트

반응식

HRID 981922 반응식
C([O:3][C:4](=O)[CH2:5][O:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:20]=1[C:19]([NH2:21])=[C:18]1[C:13]([CH2:14][CH2:15][CH2:16][CH2:17]1)=[N:12]2)C.CC(C)([O-])C.[K+].[Cl-].[NH4+]>O1CCCC1>[NH:21]1[C:19]2=[C:18]3[C:13](=[N:12][C:11]4=[CH:10][CH:9]=[CH:8][C:7](=[C:20]24)[O:6][CH2:5][C:4]1=[O:3])[CH2:14][CH2:15][CH2:16][CH2:17]3

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 20068607Ethyl[(9-amino-1,2,3,4-tetrahydroacridin-8-yl)oxy]acetateHCID 23665647Potassium tert-butoxide

생성물 1

HCID 9795016HCID 9795016, 화합물수율 82.7%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Ethyl[(9-amino-1,2,3,4-tetrahydroacridin-8-yl)oxy]acetate (14.50 g) was dissolved in dry tetrahydrofuran (350 ml) and potassium t-butoxide (6.0 g) was added. After stirring for 1 hr, 100 ml saturated ammonium chloride solution (100 ml) was added, and stirring was continued for 30 min. The reaction mixture was evaporated under reduced pressure. The solid was collected and washed with water to give 10.15 g (82.65%) of product, mp 201°-202° C.

후처리

  1. stirringstirring
  2. waitwas continued for 30 min
  3. customThe reaction mixture was evaporated under reduced pressure
  4. customThe solid was collected
  5. washwashed with water

출처 및 근거

ORD 기록
ord-02b77890b806423999df7c807a01f23d
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04994452

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