Carbon Dioxide → 1,3-Benzothiazole-2-carboxylic acid
반응식
C([Li])CCC.[S:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[CH:7]1.[C:15](=[O:17])=[O:16].O>O1CCCC1>[S:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[C:15]([OH:17])=[O:16]참가 물질
6
실험 절차
A precooled (-78° C.) solution of 7.7 ml (19.2 mmol) of n-butyllithium in 50 ml of dry tetrahydrofuran was treated dropwise with 2.0 ml (18.3 mmol) of benzothiazole. After the addition was complete, the solution was poured into a mixture of excess dry ice in 100 ml of tetrahydrofuran. After being allowed to warm, the resulting solution was treated with water, washed with ether, acidified with HCl, and filtered to give a yellow solid. Digestion with boiling ether followed by filtration gave 1.55 g (47%) of the desired compound as a nearly white solid.
후처리
- additionAfter the addition
- temperatureto warm
- washwashed with ether
- filtrationfiltered
- customto give a yellow solid
- filtrationDigestion with boiling ether followed by filtration
출처 및 근거
- ORD 기록
- ord-defdc355577a4f3f883df978a3b7f93a
- 출처 데이터셋
- uspto-grants-1991_02
- 특허 번호
- US04994477
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