Carbon Dioxide → 1,3-Benzothiazole-2-carboxylic acid

HRID 982024

반응식

HRID 982024 반응식
C([Li])CCC.[S:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[CH:7]1.[C:15](=[O:17])=[O:16].O>O1CCCC1>[S:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[C:15]([OH:17])=[O:16]

참가 물질

6

반응물 4

HCID 280Carbon DioxideHCID 962WaterHCID 7222BenzothiazoleHCID 178418339Butyllithium

생성물 1

HCID 5850531,3-Benzothiazole-2-carboxylic acid수율 47%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A precooled (-78° C.) solution of 7.7 ml (19.2 mmol) of n-butyllithium in 50 ml of dry tetrahydrofuran was treated dropwise with 2.0 ml (18.3 mmol) of benzothiazole. After the addition was complete, the solution was poured into a mixture of excess dry ice in 100 ml of tetrahydrofuran. After being allowed to warm, the resulting solution was treated with water, washed with ether, acidified with HCl, and filtered to give a yellow solid. Digestion with boiling ether followed by filtration gave 1.55 g (47%) of the desired compound as a nearly white solid.

후처리

  1. additionAfter the addition
  2. temperatureto warm
  3. washwashed with ether
  4. filtrationfiltered
  5. customto give a yellow solid
  6. filtrationDigestion with boiling ether followed by filtration

출처 및 근거

ORD 기록
ord-defdc355577a4f3f883df978a3b7f93a
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04994477

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