Boron trifluoride etherate → Ethyl (2E)-4-oxo-4-phenyl-2-butenoate

HRID 982184노트

반응식

HRID 982184 반응식
[C:1](/[CH:9]=[CH:10]\[C:11]([O:13][CH2:14][CH3:15])=[O:12])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.B(F)(F)F.CCOCC>C1(C)C=CC=CC=1>[C:1](/[CH:9]=[CH:10]/[C:11]([O:13][CH2:14][CH3:15])=[O:12])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 8000Boron trifluoride etherateHCID 10703358Ethyl cis-beta-benzoylacrylate

생성물 1

HCID 5369605Ethyl (2E)-4-oxo-4-phenyl-2-butenoate수율 87.5%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
80 °C

실험 절차

A mixture of 200 mg of ethyl cis-β-benzoylacrylate, 200 mg of boron trifluoride etherate (about 47 %) and 10 ml of toluene was stirred at 80° C. for 45 minutes and then cooled, followed by the procedure as in Example 1 to give 175 mg of ethyl trans-β-benzoylacrylate as a yellow oil.

후처리

  1. temperaturecooled

출처 및 근거

ORD 기록
ord-c1ce808d7db64590a56369cb294c846b
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04994600

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