Phenyl isocyanate → (5RS, 6SR)-6-phenyl-5-phenylcarbamoyloxy-2-(2-thienyl)-5,6-dihydro-4H-1,3-oxazine

HRID 982257노트

반응식

HRID 982257 반응식
[C:1]1([CH:7]2[O:12][C:11]([C:13]3[S:14][CH:15]=[CH:16][CH:17]=3)=[N:10][CH2:9][CH:8]2[OH:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:19]1([N:25]=[C:26]=[O:27])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[C:1]1([CH:7]2[O:12][C:11]([C:13]3[S:14][CH:15]=[CH:16][CH:17]=3)=[N:10][CH2:9][CH:8]2[O:18][C:26](=[O:27])[NH:25][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

3

반응물 2

HCID 7672Phenyl isocyanateHCID 14650616(5RS, 6SR)-6-phenyl-2-(2-thienyl)-5,6-dihydro-4H-1,3-oxazin-5-ol

생성물 1

HCID 14650703(5RS, 6SR)-6-phenyl-5-phenylcarbamoyloxy-2-(2-thienyl)-5,6-dihydro-4H-1,3-oxazine수율 77.4%

실험 절차

Working in a manner similar to that described in Example 12, but starting with (5RS, 6SR)-6-phenyl-2-(2-thienyl)-5,6-dihydro-4H-1,3-oxazin-5-ol (1.55 g) and phenyl isocyanate (0.8 g), and after recrystallization in isopropanol, (5RS, 6SR)-6-phenyl-5-phenylcarbamoyloxy-2-(2-thienyl)-5,6-dihydro-4H-1,3-oxazine (1.75 g), m.p. 98° C., is obtained.

후처리

  1. customafter recrystallization in isopropanol

출처 및 근거

ORD 기록
ord-2ed86a68dbc64c41b093204cb75cf510
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04994569

반응 노트

불러오는 중…