6-(Pyrimidin-5-YL)hex-5-YN-1-OL → 6-(Pyrimidin-5-yl)hexan-1-ol

HRID 982379노트

반응식

HRID 982379 반응식
[N:1]1[CH:6]=[C:5]([C:7]#[C:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[CH:4]=[N:3][CH:2]=1>C(O)C.[Pd]>[N:1]1[CH:6]=[C:5]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[CH:4]=[N:3][CH:2]=1

참가 물질

4

반응물 1

HCID 139997526-(Pyrimidin-5-YL)hex-5-YN-1-OL

생성물 1

HCID 135575446-(Pyrimidin-5-yl)hexan-1-ol수율 93.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매2회

실험 절차

A solution of 6-(5-pyrimidinyl)-5-hexynol (3.52 g) in ethanol (20 ml) was added to a pre-hydrogenated suspension of 10% palladium on carbon (1 g) in ethanol (130 ml) and hydrogenated at room temperature and pressure. The mixture was filtered through hyflo and the filtrate evaporated in vacuo to give the title compound as a pale yellow oil (3.38 g).

후처리

  1. filtrationThe mixture was filtered through hyflo
  2. customthe filtrate evaporated in vacuo

출처 및 근거

ORD 기록
ord-902d94ae0e6f475fb5fb49a5d36508f8
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04996218

반응 노트

불러오는 중…