[6-[(6-Bromohexyl)oxy]-1-hexynyl]pyrazine → [6-[(6-Bromohexyl)oxy]hexyl]pyrazine

HRID 982394노트

반응식

HRID 982394 반응식
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]#[C:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1>C(O)C.[Pd]>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1

참가 물질

4

반응물 1

HCID 19876775[6-[(6-Bromohexyl)oxy]-1-hexynyl]pyrazine

생성물 1

HCID 19876745[6-[(6-Bromohexyl)oxy]hexyl]pyrazine수율 87.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매2회

실험 절차

A solution of [6-[(6-bromohexyl)oxy]-1-hexynyl]pyrazine (2.76 g) in ethanol (70 ml) was added to a pre-hydrogenated suspension of 10% palladium on carbon (2.00 g) in ethanol (50 ml) and hydrogenated at room temperature and pressure for 11 h. The mixture was filtered through hyflo and evaporated in vaco to afford the title compound as a colourless oil (2.45 g), t.l.c. (ether) Rf 0.55.

후처리

  1. filtrationThe mixture was filtered through hyflo
  2. customevaporated in vaco

출처 및 근거

ORD 기록
ord-cc2096fb3ade4213ba15a74485b96ba4
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04996218

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