Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → D-leucic acid 4-nitrobenzyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Nitrobenzyl bromide | HCID 66011 | — |
| 반응물 | (R)-2-hydroxy-4-methylpentanoic acid | HCID 439960 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | D-leucic acid 4-nitrobenzyl ester | HCID 86744637 | 98% |
반응 단계
10.45 g of D-leucic acid was dissolved in 150 ml of ethyl acetate. 11 ml of triethylamine and 18.78 g of 4-nitrobenzyl bromide were added and the mixture was heated under reflux for 3 hours. The mixture was washed in sequence with water, 10% citric acid solution, saturated sodium hydrogen carbonate solution, water and saturated sodium chloride solution. After drying over anhydrous sodium sulfate and evaporation, there were obtained 20.6 g (98%) of D-leucic acid 4-nitrobenzyl ester as a gum. Rf (chloroform) 0.37.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04996358 |
| 출처 데이터셋 | uspto-grants-1991_02 |
| ORD ID | ord-09c4995c8d274c228b43eff3835e827b |
| 출처 메모 | uspto-grants-1991_02 |