Dimethyl sebacate → N,N,N',N'-tetrakis(2-hydroxyethyl)sebacamide

HRID 982587

반응식

HRID 982587 반응식
[C:1]([O:15]C)(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12]C)=O.[NH:17]([CH2:21][CH2:22][OH:23])[CH2:18][CH2:19][OH:20]>>[OH:20][CH2:19][CH2:18][N:17]([CH2:21][CH2:22][OH:23])[C:10](=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][C:1]([N:17]([CH2:21][CH2:22][OH:23])[CH2:18][CH2:19][OH:20])=[O:15]

참가 물질

3

반응물 2

HCID 7829Dimethyl sebacateHCID 8113Diethanolamine

생성물 1

HCID 231267N,N,N',N'-tetrakis(2-hydroxyethyl)sebacamide

반응 조건

온도
140 °C

실험 절차

A mixture of 57.58 g (0.25 mol) dimethyl sebacate and 157.71 g (1.50 mol) of diethanolamine was heated in a 140° C. bath under nitrogen for 2.5 hrs while collecting the methanol condensate. The reaction mixture was subsequently heated in a 200° C. at reduced pressure (1.5 mm) to distill off excess diethanolamine. The highly viscous oily residue was dissolved in an equal volume of acetone and stirred overnight. The resulting crystalline solid was collected, washed with acetone, and dried. The yield of product was 35.0 g (9.3% of theory); mp=87-98° C.

후처리

  1. customwhile collecting the methanol condensate
  2. temperatureThe reaction mixture was subsequently heated in a 200° C. at reduced pressure (1.5 mm)
  3. distillationto distill off excess diethanolamine
  4. dissolutionThe highly viscous oily residue was dissolved in an equal volume of acetone
  5. customThe resulting crystalline solid was collected
  6. washwashed with acetone
  7. customdried

출처 및 근거

ORD 기록
ord-f811ec377c934eb9b5c669d0d761692b
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06861192B2

연결된 노트

불러오는 중…