2-(2-Chlorophenyl)ethyl methanesulfonate → 2-[2-(2-chlorophenyl)ethyl]-6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

HRID 982825노트

반응식

HRID 982825 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:15]([O:17][CH3:18])=[O:16])[C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][C:3]=1[CH3:19].CS(O[CH2:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[Cl:33])(=O)=O>>[Cl:33][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=1[CH2:26][CH2:25][N:12]1[C:11](=[O:14])[C:10]([C:15]([O:17][CH3:18])=[O:16])=[CH:9][C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[C:3]([CH3:19])[CH:4]=2)=[N:13]1

참가 물질

3

반응물 2

HCID 218880872-(2-Chlorophenyl)ethyl methanesulfonateHCID 219914596-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

생성물 1

HCID 225622482-[2-(2-chlorophenyl)ethyl]-6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one수율 59.8%

실험 절차

Following the procedure of Example 1(6), 6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one and 2-(2-chlorophenyl)ethanol methanesulfonate were reacted to yield the title compound as a pale yellow solid (yield: 59.8%).

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-11cf328b860b422bb54e1a25c3c40802
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06861428B2

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