4-azidomethyl-5-methyl-2-phenyl-1H-imidazole → C-(5-methyl-2-phenyl-1H-imidazol-4-yl)-methylamine
반응식
[N:1]([CH2:4][C:5]1[N:6]=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:8][C:9]=1[CH3:10])=[N+]=[N-]>C(O)C.[Pd]>[CH3:10][C:9]1[NH:8][C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:6][C:5]=1[CH2:4][NH2:1]참가 물질
4
실험 절차
To solution of 4-azidomethyl-5-methyl-2-phenyl-1H-imidazole (1.22 g) in ethanol (50 ml) was added 10% Pd/C (0.10 g). The reaction mixture was hydrogenated at room temperature and 1.1 bar for 30 minutes, the catalyst was filtered off over a pad of celite. The filtrate was evaporated to dryness under high vacuum to obtain C-(5-methyl-2-phenyl-1H-imidazol-4-yl)-methylamine (1.06 g) as a light yellow foam which was sufficiently pure to be used directly in the next step.
후처리
- customwas hydrogenated at room temperature
- filtrationthe catalyst was filtered off over a pad of celite
- customThe filtrate was evaporated to dryness under high vacuum
출처 및 근거
- ORD 기록
- ord-c7bdcad7f7af4e7888728e99ebd7b87a
- 출처 데이터셋
- uspto-grants-2005_03
- 특허 번호
- US06861440B2
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