Chloroacetyl chloride → HCID 2063649, 화합물
반응식
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])[CH3:2].C(N(CC)CC)C.[Cl:19][CH2:20][C:21](Cl)=[O:22]>C(Cl)Cl>[CH2:1]([O:3][C:4]([N:6]1[CH2:7][CH2:8][N:9]([C:21]([CH2:20][Cl:19])=[O:22])[CH2:10][CH2:11]1)=[O:5])[CH3:2]참가 물질
5
실험 절차
To a solution of 1-ethoxycarbonylpiperazine (1.5 mL, 10 mmol) in 40 mL CH2Cl2, was added triethylamine (2 mL, 14 mmol) and chloroacetyl chloride (0.8 mL, 5.0 mmol) at 0° C. The resulting reaction mixture was stirred at amibent temperature for 2 hours. The reaction mixture was washed with water, 2N NaHSO4 and brine, and dried over sodium sulfate. The solvent was evaporated in vacuo to afford 1-ethoxycarbonyl-4-chloromethylcarbonylpiperazine (4.5 g) as an yellow oil, which was used without further purification.
후처리
- customThe resulting reaction mixture
- washThe reaction mixture was washed with water, 2N NaHSO4 and brine
- dry with materialdried over sodium sulfate
- customThe solvent was evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-e6435ace51a94eb7a381402bfc2aaf91
- 출처 데이터셋
- uspto-grants-2005_03
- 특허 번호
- US06861424B2
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