Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → 5-Formyl-4-methyl-1H-pyrrole-3-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Ethyl 5-formyl-4-methyl-1h-pyrrole-3-carboxylate | HCID 236067 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-Formyl-4-methyl-1H-pyrrole-3-carboxylic acid | HCID 22135453 | 87.5% |
반응 단계
KOH (5 g, 2 eq) was added to a suspension of 5-formyl-4-methyl-1H-pyrrole-3-carboxylic acid ethyl ester (8.13 g, 44.8 mmol) in water (100 mL) and EtOH (50 mL) with stirring. The mixture was heated to reflux for 2.5 hr, cooled to rt, concentrated to about ⅔ volume, diluted with water (300 mL) and acidified to pH=3 using 1N HCl. The white solid was collected by filtration and dried to afford 6 g (87%) of 5-formyl-4-methyl-1H-pyrrole-3-carboxylic acid as a tan solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06861418B2 |
| 출처 데이터셋 | uspto-grants-2005_03 |
| ORD ID | ord-1ad93bea9e8d48e8afd14a00e43dc147 |
| 출처 메모 | uspto-grants-2005_03 |