Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1,4,5,6,7,8-Hexahydropyrrolo[3,2-B]azepine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Fluoride | HCID 5235 | — |
| 반응물 | Diisobutylaluminum hydride | HCID 14487 | — |
| 반응물 | 1,5,6,7-Tetrahydro-indol-4-one oxime | HCID 915677 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1,4,5,6,7,8-Hexahydropyrrolo[3,2-B]azepine | HCID 22561790 | 33.4% |
반응 단계
To a stirred solution of 1,5,6,7-tetrahydro-indol-4-one oxime (1.2 g, 7.7 mmol) in DCM (anhydrous, 250 mL) was added DIBAL-H (1M solution in DCM, 35 mL) at 0° C. under nitrogen. After 2 hours, NaF (7 g) was added followed by water (2.24 g). After 20 mins, the reaction was filtered through celite and the solvent was removed to give 350 mg of 1,4,5,6,7,8-hexahydro-pyrrolo[3,2-b]azepine as a brown oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06861418B2 |
| 출처 데이터셋 | uspto-grants-2005_03 |
| ORD ID | ord-9a2c8b4b72344aa88edb49d8d0bfed8a |
| 출처 메모 | uspto-grants-2005_03 |