Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Iodo-1-propanol → N-(3,5-Difluorophenylacetyl)-L-alaninyl-L-phenylalanine 3-Iodopropyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Iodo-1-propanol | HCID 69390 | — |
| 반응물 | N-(N-(3,5-difluorophenylacetyl)-L-alaninyl]-L-phenylalanine | HCID 22895006 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | N-(3,5-Difluorophenylacetyl)-L-alaninyl-L-phenylalanine 3-Iodopropyl Ester | HCID 9807836 | — |
반응 단계
Following General Procedure B and using N-[N-(3,5-difluorophenylacetyl)-L-alaninyl]-L-phenylalanine (prepared by coupling N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and L-phenylalanine (Aldrich) using General Procedure B) and 3-iodo-1-propanol (Aldrich), the title compound was prepared as a solid. The reaction was monitored by tlc (Rf=0.45 in 5% MeOH/methylene chloride) and the product was purified by preparative tlc using 5% MeOH/methylene chloride.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06861558B2 |
| 출처 데이터셋 | uspto-grants-2005_03 |
| ORD ID | ord-36d4dee0848740c0959bf371a6919c83 |
| 출처 메모 | uspto-grants-2005_03 |