Cyclamate → Cyclohexylsulfamyl chloride

HRID 983386

반응식

HRID 983386 반응식
[CH:1]1([NH:7][S:8](=[O:11])(=O)[OH:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.P(Cl)(Cl)(Cl)(Cl)[Cl:13]>C1C=CC=CC=1>[CH:1]1([NH:7][S:8]([Cl:13])(=[O:11])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 7533CyclamateHCID 24819Phosphorus pentachloride

생성물 1

HCID 12914615Cyclohexylsulfamyl chloride수율 91%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To a solution of cyclohexylsulfamic acid (5 g, 27.9 mmol) in benzene (30 mL) was added dropwise phosphorus pentachloride (6.4 g, 30.7 mmol), and the mixture heated at reflux for 4 h. After the solvent was removed, the residue was distilled under reduced pressure to give the title compound (5 g, 91%).

후처리

  1. temperaturethe mixture heated
  2. temperatureat reflux for 4 h
  3. customAfter the solvent was removed
  4. distillationthe residue was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-a76075b7f38b47758adefd0f59f0adb2
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06864249B2

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