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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Triethylamine → (1-Benzo[1,3]dioxol-5-yl-1,3,4,9-tetrahydro-beta-carbolin-2-yl)-[5-(3-trifluoromethyl-phenyl)-furan-2-yl]-methanone

HRID 983416
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HRID 983416 반응식
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([C:9]2[O:13][C:12]([C:14]([OH:16])=O)=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1.C(Cl)(=O)C(Cl)=O.[CH2:25]1[O:33][C:32]2[CH:31]=[CH:30][C:29]([CH:34]3[C:46]4[NH:45][C:44]5[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=5)[C:38]=4[CH2:37][CH2:36][NH:35]3)=[CH:28][C:27]=2[O:26]1.C(N(CC)CC)C>C(Cl)Cl.CN(C=O)C>[CH2:25]1[O:33][C:32]2[CH:31]=[CH:30][C:29]([CH:34]3[C:46]4[NH:45][C:44]5[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=5)[C:38]=4[CH2:37][CH2:36][N:35]3[C:14]([C:12]3[O:13][C:9]([C:5]4[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:18])[F:17])[CH:4]=4)=[CH:10][CH:11]=3)=[O:16])=[CH:28][C:27]=2[O:26]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 65578Oxalyl chlorideHCID 2011721-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-beta-carbolineHCID 6882815-(3-(Trifluoromethyl)phenyl)-2-furoic acid

생성물 1

HCID 12020635(1-Benzo[1,3]dioxol-5-yl-1,3,4,9-tetrahydro-beta-carbolin-2-yl)-[5-(3-trifluoromethyl-phenyl)-furan-2-yl]-methanone

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매
HCID 6344Dichloromethane용매2회

실험 절차

To a suspension of 5-(3-trifluoromethylphenyl)furoic acid (256 mg, 1 mmol) in DCM (20 mL, anhydrous) was added oxalyl chloride (165 mg, 1.3 mmol), followed by two drops of DMF. The mixture was stirred at room temperature for 1 h. A solution of 1-(3,4-methylenedioxyphenyl)-2,3,4,9-tetrahydro-1H-β-carboline (292 mg, 1 mmol) (prepared according to the process as disclosed in WO97/43287, Intermediate 7, page 24) and triethylamine (0.4 mL) in DCM (10 mL, anhydrous) was added and the mixture was stirred at room temperature for 16 h, washed sequentially with aqueous NaHCO3, brine (2×), 1N HCl and brine (2×) and dried with MgSO4. After evaporation of the solvent, a white solid was obtained.

후처리

  1. additionwas added
  2. stirringthe mixture was stirred at room temperature for 16 h
  3. washwashed sequentially with aqueous NaHCO3, brine (2×), 1N HCl and brine (2×)
  4. dry with materialdried with MgSO4
  5. customAfter evaporation of the solvent
  6. customa white solid was obtained

출처 및 근거

ORD 기록
ord-3d91dc99fc354d4f99eb42b7ef3fbacb
출처 데이터셋
uspto-grants-2005_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06864253B2

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