Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1-Benzyl-5-nitro-1H-indazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Nitroindazole | HCID 21501 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-Benzyl-5-nitro-1H-indazole | HCID 21952082 | — |
| 생성물 | 2-benzyl-5-nitro-1H-indazole | HCID 22560083 | — |
반응 단계
To a solution of 5-nitroindazole (10 g, 61.3 mmol) in DMF (100 mL) was added K2CO3 (12.7 g, 91.9 mmol) and PhCH2Br (7.29 mL, 61.3 mmol). The resulting mixture was stirred at RT for 3.5 days, then poured into 400 mL of H2O. The resulting slurry was filtered, rinsed once with water and dried in vacuo giving a beige solid. A portion of this crude material (2.5 g) was purified by chromatography (SiO2, elution with 1:2 EtOAc-hexanes) giving 1-benzyl-5-nitro-1H-indazole and 2-benzyl-5-nitro-1H-indazole.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06864255B2 |
| 출처 데이터셋 | uspto-grants-2005_03 |
| ORD ID | ord-a143097e57ae4084916693887d2a7f21 |
| 출처 메모 | uspto-grants-2005_03 |