Trifluoroacetic acid → (7-Nitro-1,2,3,4-tetrahydro-naphthalen-2-yl)-piperidin-4-ylmethyl-propyl-amine

HRID 983467노트

반응식

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]([CH:19]2[CH2:28][CH2:27][C:26]3[C:21](=[CH:22][C:23]([N+:29]([O-:31])=[O:30])=[CH:24][CH:25]=3)[CH2:20]2)[CH2:16][CH2:17][CH3:18])[CH2:10][CH2:9]1)=O)(C)(C)C.C(NC(N1CCC(CN(CC)C2CCC3C(=CC(NC(=O)C4C=CC(S(C)(=O)=O)=CC=4)=CC=3)C2)CC1)=O)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[N+:29]([C:23]1[CH:22]=[C:21]2[C:26]([CH2:27][CH2:28][CH:19]([N:15]([CH2:14][CH:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH2:16][CH2:17][CH3:18])[CH2:20]2)=[CH:25][CH:24]=1)([O-:31])=[O:30]

참가 물질

실험 절차

To a solution of 4-{[(7-nitro-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester, prepared as in Example 1 (1.12 g, 2.60 mmol) in methylene chloride (30 mL) under a nitrogen atmosphere was added trifluoroacetic acid (10 mL). The reaction was stirred at room temperature for 30 min. and concentrated in vacuo. The residue was partitioned between EtOAc (50 mL) and 10% aq. KOH (50 mL). The organic layer was separated, dried over MgSO4, filtered, and concentrated to afford (7-nitro-1,2,3,4-tetrahydro-naphthalen-2-yl)-piperidin-4-ylmethyl-propyl-amine (845 mg).

후처리

concentrationconcentrated in vacuo
customThe residue was partitioned between EtOAc (50 mL) and 10% aq. KOH (50 mL)
customThe organic layer was separated
dry with materialdried over MgSO4
filtrationfiltered
concentrationconcentrated

출처 및 근거

ORD 기록: ord-558022e12e69458f98adbfcf49d5a06f
출처 데이터셋: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06864266B2

반응 노트

불러오는 중…

반응식

참가 물질

반응물 3

생성물 1

시약·촉매·용매 1

실험 절차

후처리

출처 및 근거

반응 노트