참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Benzaldehyde, 4-[[2-(acetyloxy)ethyl]ethylamino]- | HCID 11458991 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-(Ethyl(2-hydroxyethyl)amino)benzaldehyde | HCID 639857 | — |
반응 단계
A 150 ml of NaOH-solution (5 M in water) is added to a solution of 59.2 g (252 mmol) of 17 in 200 ml of ethanol and the mixture is stirred overnight at 40° C. The reaction mixture is cooled in an ice bath and neutralized with HCl (5 M) and extracted with dichloromethane. The organic layer is washed with a saturated NaHCO3-solution, with brine and dried over MgSO4. The solvents are evaporated under reduced pressure. The product is isolated as an oil and used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06864347B2 |
|---|
| 출처 데이터셋 | uspto-grants-2005_03 |
|---|
| ORD ID | ord-067bfc77490a46de92e6cddc0813553f |
|---|
| 출처 메모 | uspto-grants-2005_03 |
|---|
