Hydrochloric Acid → 4-(Ethyl(2-hydroxyethyl)amino)benzaldehyde

HRID 983575

반응식

HRID 983575 반응식
[OH-].[Na+].[CH2:3]([N:5]([CH2:14][CH2:15][O:16]C(=O)C)[C:6]1[CH:11]=[CH:10][C:9]([CH:12]=[O:13])=[CH:8][CH:7]=1)[CH3:4].Cl>C(O)C>[CH2:3]([N:5]([C:6]1[CH:7]=[CH:8][C:9]([CH:12]=[O:13])=[CH:10][CH:11]=1)[CH2:14][CH2:15][OH:16])[CH3:4]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 11458991Benzaldehyde, 4-[[2-(acetyloxy)ethyl]ethylamino]-

생성물 1

HCID 6398574-(Ethyl(2-hydroxyethyl)amino)benzaldehyde

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
40 °C

실험 절차

A 150 ml of NaOH-solution (5 M in water) is added to a solution of 59.2 g (252 mmol) of 17 in 200 ml of ethanol and the mixture is stirred overnight at 40° C. The reaction mixture is cooled in an ice bath and neutralized with HCl (5 M) and extracted with dichloromethane. The organic layer is washed with a saturated NaHCO3-solution, with brine and dried over MgSO4. The solvents are evaporated under reduced pressure. The product is isolated as an oil and used without further purification.

후처리

  1. temperatureThe reaction mixture is cooled in an ice bath
  2. extractionextracted with dichloromethane
  3. washThe organic layer is washed with a saturated NaHCO3-solution, with brine
  4. dry with materialdried over MgSO4
  5. customThe solvents are evaporated under reduced pressure
  6. customThe product is isolated as an oil
  7. customused without further purification

출처 및 근거

ORD 기록
ord-067bfc77490a46de92e6cddc0813553f
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06864347B2

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