Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 5-tert-butyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 5-tert-butyl-1H-imidazole | HCID 498436 | — |
| 반응물 | 2-Chloromethyl 2-(trimethylsilyl)ethyl ether | HCID 2724271 | — |
| 생성물 | 5-tert-butyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole | HCID 22018569 | 57.6% |
반응 단계
Reaction of 5-tert-butyl-1H-imidazole (423 mg, 3.41 mmol), NaH (60%, 132 mg, 3.31 mmol), and SEMCl (639 uL, 3.61 mmol) followed by column chromatography on silica gel (hexane/EtOAC 3:2) gave the title compound (500 mg, 57%) as a yellow oil. 1H NMR (300 MHz, CDCl3) δ major isomer: 0.00 (s, 9H), 0.89 (t, 2H, J=7.5 Hz), 1.29 (s, 9H), 3.47 (t, 2H, J=7.5 Hz), 5.19 (s, 2H), 6.73 (s, 1H), 7.50 (s, 1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06864265B2 |
| 출처 데이터셋 | uspto-grants-2005_03 |
| ORD ID | ord-0a0e3ab9f473443fad7ae8fa40b424dd |
| 출처 메모 | uspto-grants-2005_03 |