2,4-Dichlorobenzylidenemalononitrile → 5-Aminomethyl-6-(2,4-dichloro-phenyl)-2-pyrrolidin-1-yl-pyrimidin-4-ylamine

HRID 983845노트

반응식

HRID 983845 반응식
[N:1]1([C:6]([NH2:8])=[NH:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:9][C:10]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:11]=1[CH:12]=[C:13]([C:16]#[N:17])[C:14]#[N:15]>>[NH2:17][CH2:16][C:13]1[C:14]([NH2:15])=[N:7][C:6]([N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[N:8][C:12]=1[C:11]1[CH:18]=[CH:19][C:20]([Cl:22])=[CH:21][C:10]=1[Cl:9]

참가 물질

3

반응물 2

HCID 180892,4-DichlorobenzylidenemalononitrileHCID 2794597Pyrrolidine-1-carboximidamide

생성물 1

HCID 101258855-Aminomethyl-6-(2,4-dichloro-phenyl)-2-pyrrolidin-1-yl-pyrimidin-4-ylamine

실험 절차

The title compound, MS: m/e=337.8 (M+), was prepared from pyrrolidine-1-carboxamidine and 2-(2,4-dichloro-benzylidene)-malononitrile in analogy to the process described in Example 11 as a solid.

출처 및 근거

ORD 기록
ord-48da1a1ee36a48959c27585c6b19fa88
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06867205B2

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