2-(6-bromo-1H-indol-3-yl)acetamide → 3-(6-Bromo-1H-indol-3-yl)-4-(5-hydroxymethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-pyrrolidine-2,5-dione

HRID 983991노트

반응식

HRID 983991 반응식
C[O:2][C:3](=O)[C:4]([C:6]1[C:16]2=[C:17]3[C:12](=[CH:13][CH:14]=[CH:15]2)[CH2:11][CH:10]([CH2:18][OH:19])[CH2:9][N:8]3[CH:7]=1)=O.[Br:21][C:22]1[CH:30]=[C:29]2[C:25]([C:26]([CH2:31][C:32]([NH2:34])=[O:33])=[CH:27][NH:28]2)=[CH:24][CH:23]=1>>[Br:21][C:22]1[CH:30]=[C:29]2[C:25]([C:26]([CH:31]3[CH:4]([C:6]4[C:16]5=[C:17]6[C:12](=[CH:13][CH:14]=[CH:15]5)[CH2:11][CH:10]([CH2:18][OH:19])[CH2:9][N:8]6[CH:7]=4)[C:3](=[O:2])[NH:34][C:32]3=[O:33])=[CH:27][NH:28]2)=[CH:24][CH:23]=1

참가 물질

3

반응물 2

HCID 234276092-(6-bromo-1H-indol-3-yl)acetamideHCID 69742637(5-(hydroxymethyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl]oxo-acetic acid methyl ester

생성물 1

HCID 225566833-(6-Bromo-1H-indol-3-yl)-4-(5-hydroxymethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-pyrrolidine-2,5-dione

실험 절차

Beginning with (5-(hydroxymethyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl]oxoacetic acid methyl ester and (6-bromo-1H-indol-3-yl)acetamide, the title compound was prepared essentially as described in Example 1.

출처 및 근거

ORD 기록
ord-5bc5b8a7776d4791b8ed03b549c586e9
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06867198B2

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