{6-[4-Methyl-2-(4-Trifluoromethyl-Phenyl)-Thiazol-5-Ylmethylsulfanyl]-3,4-Dihydro-1H-Isoquinolin-2-Yl}-Acetic Acid Methyl Ester → (6-Mercapto-3,4-Dihydro-1H-Isoquinolin-2-Yl)-Acetic Acid Methyl Ester

반응식

COC(C1CC2C(=CC=C(S)C=2)C1)=O.[CH3:15][O:16][C:17](=[O:47])[CH2:18][N:19]1[CH2:28][CH2:27][C:26]2[C:21](=[CH:22][CH:23]=[C:24]([S:29]CC3SC(C4C=CC(C(F)(F)F)=CC=4)=NC=3C)[CH:25]=2)[CH2:20]1>>[CH3:15][O:16][C:17](=[O:47])[CH2:18][N:19]1[CH2:28][CH2:27][C:26]2[C:21](=[CH:22][CH:23]=[C:24]([SH:29])[CH:25]=2)[CH2:20]1

참가 물질

반응물 2

HCID 20765977{6-[4-Methyl-2-(4-Trifluoromethyl-Phenyl)-Thiazol-5-Ylmethylsulfanyl]-3,4-Dihydro-1H-Isoquinolin-2-Yl}-Acetic Acid Methyl Ester2회

HCID 207660125-Mercapto-Indan-2-Carboxylic Acid Methyl Ester

생성물 1

HCID 20765990(6-Mercapto-3,4-Dihydro-1H-Isoquinolin-2-Yl)-Acetic Acid Methyl Ester수율 74%

실험 절차

10C was prepared analogously to compound 1C. 74% yield. MS: 238 (M+1)+. Preparation of {6-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-3,4-dihydro-1H-isoquinolin-2-yl}-acetic acid methyl ester (Compound 10D)

출처 및 근거

ORD 기록: ord-4f1205f008e24ec1a2cac2a5ffcf942c
출처 데이터셋: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06867224B2

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