5-Mercapto-Indan-2-Carboxylic Acid Methyl Ester → (6-Mercapto-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-acetic acid methyl ester

HRID 984112노트

반응식

HRID 984112 반응식
COC(C1CC2C(=CC=C(S)C=2)C1)=O.[CH3:15][O:16][C:17](=[O:48])[CH2:18][N:19]1[C:28]2[C:23](=[CH:24][C:25]([S:29]CC3SC(C4C=CC(C(F)(F)F)=CC=4)=NC=3C)=[CH:26][CH:27]=2)[CH2:22][CH2:21][C:20]1=[O:47]>>[CH3:15][O:16][C:17](=[O:48])[CH2:18][N:19]1[C:28]2[C:23](=[CH:24][C:25]([SH:29])=[CH:26][CH:27]=2)[CH2:22][CH2:21][C:20]1=[O:47]

참가 물질

3

반응물 2

HCID 207660125-Mercapto-Indan-2-Carboxylic Acid Methyl EsterHCID 69590773{6-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-2-oxo-3,4-dihydro-2H-quinolin-1-yl}-acetic acid methyl ester2회

생성물 1

HCID 20770803(6-Mercapto-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-acetic acid methyl ester수율 92%

실험 절차

12C was prepared analogously to compound 1C. 92% yield. MS: 252 (M+1)+. Preparation of {6-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-2-oxo-3,4-dihydro-2H-quinolin-1-yl}-acetic acid methyl ester (Compound 12D)

출처 및 근거

ORD 기록
ord-3c731d1e71e8448ea1149349ca2f49d3
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06867224B2

반응 노트

불러오는 중…