methyl 2H-chromene-3-carboxylate → Methyl chroman-3-carboxylate

반응식

[CH3:1][O:2][C:3]([C:5]1[CH2:6][O:7][C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:4].COC(C1CC2C(=CC=C(S(Cl)(=O)=O)C=2)OC1)=O>>[CH3:1][O:2][C:3]([CH:5]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[O:7][CH2:6]1)=[O:4]

참가 물질

반응물 2

HCID 1475903methyl 2H-chromene-3-carboxylate

HCID 20766016Methyl 6-(chlorosulfonyl)chromane-3-carboxylate2회

생성물 1

HCID 14838402Methyl chroman-3-carboxylate

실험 절차

Compound 17A was prepared according to the method of example 3A utilizing compound 16C. Compound 17A was prepared in 95% yield. MS: 193 (M−1)+. Preparation of 6-Chlorosulfonyl-chroman-3-carboxylic acid methyl ester (Compound 17B)

후처리

customCompound 17A was prepared

출처 및 근거

ORD 기록: ord-389d14d3b01945c5889958c4af514a89
출처 데이터셋: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06867224B2

반응 노트

불러오는 중…