HCID 20765950, 화합물 → HCID 21949492, 화합물

반응식

[C:1]([CH2:3][CH:4]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([S:14](Cl)(=O)=O)[CH:11]=2)[O:6][CH2:5]1)#[N:2].CC1N=C(C2C=CC(C(F)(F)F)=CC=2)SC=1CSC1C=C2C(=CC=1)OCC(CC#N)C2>>[SH:14][C:10]1[CH:11]=[C:12]2[C:7](=[CH:8][CH:9]=1)[O:6][CH2:5][CH:4]([CH2:3][C:1]#[N:2])[CH2:13]2

참가 물질

반응물 2

HCID 20765950HCID 20765950, 화합물

HCID 21949467HCID 21949467, 화합물

생성물 1

HCID 21949492HCID 21949492, 화합물

실험 절차

Compound 18E was prepared according to the method of example 1C utilizing compound 18D. Compound 18E was prepared in 35% yield. MS: 204 (M−1)+. Preparation of 6-[4-Methyl-2-(4-trifluoromethyl-pheny)-thiazol-5-ylmethylsulfanyl]-chroman-3-yl-acetonitrile (Compound 18F)

후처리

customCompound 18E was prepared

출처 및 근거

ORD 기록: ord-f539debde3384d11b08e0cfe5f568505
출처 데이터셋: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06867224B2

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