5-Mercapto-Indan-2-Carboxylic Acid Methyl Ester → (5-Mercapto-6-methoxy-indan-1-yl)-acetic acid ethyl ester

반응식

[CH3:1]OC(C1CC2C(=CC=C(S)C=2)C1)=O.[CH3:15][O:16][C:17](=[O:48])[CH2:18][CH:19]1[C:27]2[C:22](=[CH:23][C:24]([S:30]CC3SC(C4C=CC(C(F)(F)F)=CC=4)=NC=3C)=[C:25]([O:28][CH3:29])[CH:26]=2)[CH2:21][CH2:20]1>>[CH2:15]([O:16][C:17](=[O:48])[CH2:18][CH:19]1[C:27]2[C:22](=[CH:23][C:24]([SH:30])=[C:25]([O:28][CH3:29])[CH:26]=2)[CH2:21][CH2:20]1)[CH3:1]

참가 물질

반응물 2

HCID 207660125-Mercapto-Indan-2-Carboxylic Acid Methyl Ester

HCID 69590840{6-Methoxy-5-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-indan-1-yl}-acetic acid methyl ester2회

생성물 1

HCID 20765962(5-Mercapto-6-methoxy-indan-1-yl)-acetic acid ethyl ester

실험 절차

19C was prepared analogously to compound 1C. Used as unpurified oil. MS: 267 (M+1)+. Preparation of {6-Methoxy-5-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-indan-1-yl}-acetic acid methyl ester (Compound 19D)

출처 및 근거

ORD 기록: ord-7131c44441034852ac9910532c106e0f
출처 데이터셋: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06867224B2

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