4-(Trifluoromethoxy)aniline → 1-(Tert-butoxycarbonyl)-4-[[4-(trifluoromethoxy)phenyl]amino]piperidine

반응식

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:15][C:16]([F:26])([F:25])[O:17][C:18]1[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:22][C:21]2[CH:23]=[CH:24][C:18]([O:17][C:16]([F:15])([F:25])[F:26])=[CH:19][CH:20]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

반응물 2

HCID 6008484-(Trifluoromethoxy)aniline

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

생성물 1

HCID 66237091-(Tert-butoxycarbonyl)-4-[[4-(trifluoromethoxy)phenyl]amino]piperidine

실험 절차

1-(tert-Butoxycarbonyl)-4-piperidone (5.00 g) and 4-(trifluoromethoxy)aniline (4.23 g) was treated in the same manner as described in Preparation Example 37 to give white powder of the title compound.

후처리

customas described in Preparation Example 37

출처 및 근거

ORD 기록: ord-92fa68d460a645a490eab0ce62bf4322
출처 데이터셋: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06867221B2

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