Diisobutylaluminum hydride → (E)-3-(2',3'-dichloro-biphenyl-4-yl)-but-2-en-1-ol

HRID 984328노트

반응식

HRID 984328 반응식
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12](/[C:15](/[CH3:22])=[CH:16]/[C:17](OCC)=[O:18])=[CH:11][CH:10]=1.CC(C[AlH]CC(C)C)C>>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12](/[C:15](/[CH3:22])=[CH:16]/[CH2:17][OH:18])=[CH:11][CH:10]=1

참가 물질

3

반응물 2

HCID 14487Diisobutylaluminum hydrideHCID 22557696(E)-Ethyl 3-(2',3'-dichloro-biphenyl-4-yl)-but-2-enoate

생성물 1

HCID 69801043(E)-3-(2',3'-dichloro-biphenyl-4-yl)-but-2-en-1-ol

실험 절차

(E)-Ethyl 3-(2′,3′-dichloro-biphenyl-4-yl)-but-2-enoate (1.07 g, 3.19 mmol) was reduced with DIBAL-H by a procedure analogous to that described in example 52 b to give (E)-3-(2′,3′-dichloro-biphenyl-4-yl)-but-2-en-1-ol as a colourless solid; 0.74 g (79%).

출처 및 근거

ORD 기록
ord-cc7115deecd34c90b6f9bb0f72a675a6
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06867218B2

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