2,5-Dimethoxyphenylboronic acid → (E)-ethyl 3-(2',5'-dimethoxy-biphenyl-4-yl)-but-2-enoate

반응식

Br[C:2]1[CH:7]=[CH:6][C:5](/[C:8](/[CH3:15])=[CH:9]/[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1.[CH3:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][C:19]=1B(O)O>>[CH3:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][C:19]=1[C:2]1[CH:7]=[CH:6][C:5](/[C:8](/[CH3:15])=[CH:9]/[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 27343422,5-Dimethoxyphenylboronic acid

HCID 15933615(E)-ethyl 3-(4-bromophenyl)-but-2-enoate

생성물 1

HCID 22557594(E)-ethyl 3-(2',5'-dimethoxy-biphenyl-4-yl)-but-2-enoate

실험 절차

The colourless oil, (E)-ethyl 3-(2′,5′-dimethoxy-biphenyl-4-yl)-but-2-enoate was prepared from (E)-ethyl 3-(4-bromophenyl)-but-2-enoate (example 50a) and 2,5-dimethoxyphenyl boronic acid by a procedure analogous to that described in example 52a.

출처 및 근거

ORD 기록: ord-8105724f23a844008f1e0e78700f1a3e
출처 데이터셋: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06867218B2

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