Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylene Glycol → N-benzyl-4-chloroaniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethylene Glycol | HCID 174 | — |
| 반응물 | Benzylamine | HCID 7504 | — |
| 반응물 | 1-Chloro-4-iodobenzene | HCID 12510 | — |
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 용매 | Ethyl acetate hexane | HCID 21226206 | — |
| 생성물 | N-benzyl-4-chloroaniline | HCID 76281 | 84% |
반응 단계
The general procedure under argon was followed using copper(I) iodide (10 mg, 0.05 mmol), K3PO4 (425 mg, 2.00 mmol), benzylamine (131 μL, 1.20 mmol), 4-chloroiodobenzene (239 mg, 1.00 mmol), ethylene glycol (111 μL, 2.00 mmol) and 2-propanol (1.0 mL). Column chromatography using a solvent mixture (hexane/ethyl acetate=10/1, Rf=0.4) afforded N-(4-chlorophenyl)benzylamine (182 mg, 84% isolated yield) as light yellow liquid. The spectral data (1H NMR) matched with the literature references and GC analysis indicated >95% purity. See Burton, R. D.; Bartberger, M. D.; Zhang, Y.; Eyler, J. R.; Schanze, K. S. J. Am. Chem. Soc. 1996, 118, 5655-5664.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06867298B2 |
| 출처 데이터셋 | uspto-grants-2005_03 |
| ORD ID | ord-7b92859995b6480895a77d0ef477857d |
| 출처 메모 | uspto-grants-2005_03 |