HCID 21873953, 화합물 → HCID 21873942, 화합물

HRID 985078노트

반응식

HRID 985078 반응식
[NH2:1][C:2]1[C:3]2[N:4]([C:18]([CH3:22])=[C:19]([CH3:21])[N:20]=2)[CH:5]=[CH:6][C:7]=1[C:8](=[O:17])[CH:9]1[O:16][CH:10]1[C:11]1[CH:15]=[CH:14][S:13][CH:12]=1>FC(F)(F)C(O)C(F)(F)F>[OH:16][CH:9]1[C:8](=[O:17])[C:7]2[CH:6]=[CH:5][N:4]3[C:18]([CH3:22])=[C:19]([CH3:21])[N:20]=[C:3]3[C:2]=2[NH:1][CH:10]1[C:11]1[CH:15]=[CH:14][S:13][CH:12]=1

참가 물질

3

반응물 1

HCID 21873953HCID 21873953, 화합물

생성물 1

HCID 21873942HCID 21873942, 화합물수율 6.4%

시약·촉매·용매 1

HCID 135291,1,1,3,3,3-Hexafluoro-2-propanol용매

실험 절차

1.1 g of 8-amino-7-[2,3-epoxy-1-oxo-3-(3-thienyl)propyl]-2,3-dimethylimidazo[1,2-a]pyridine are dissolved in 20 ml of hexafluoroisopropanol at room temperature, the solvent is stripped off after 19 hours and the residue is purified on silica gel (eluent: methylene chloride/methanol=100/3). 70 mg of the title compound of m.p. 222-25° C. (diethyl ether) are obtained.

후처리

  1. customthe residue is purified on silica gel (eluent: methylene chloride/methanol=100/3)

출처 및 근거

ORD 기록
ord-696db160450143b780ded95f7bfbd4da
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06869949B2

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