HCID 60128540, 화합물 → (3R,4S)-3,4-Dimethoxypyrrolidine

HRID 985193노트

반응식

HRID 985193 반응식
C(OC([N:11]1[CH2:15][C@H:14]([O:16][CH3:17])[C@H:13]([O:18][CH3:19])[CH2:12]1)=O)C1C=CC=CC=1>CO.[Pd]>[CH3:19][O:18][C@H:13]1[C@@H:14]([O:16][CH3:17])[CH2:15][NH:11][CH2:12]1

참가 물질

4

반응물 1

HCID 60128540HCID 60128540, 화합물

생성물 1

HCID 20745983(3R,4S)-3,4-Dimethoxypyrrolidine수율 99%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a stirred solution of 3,4-cis-dimethoxy-pyrrolidine-1-carboxylic acid benzyl ester 5b (16.95 g, 63.9 mmole) in MeOH (150 ml) was added 10% Pd on C (1.3 g). The mixture was stirred under H2 balloon at room temperature for 3 hours and filtered through celite. The filtrate was concentrated, in vacuo, re-dissolved in CH2Cl2 and dried over Na2SO4. The solution was concentrated to give 8.3 g (99%) of a yellow oil. 1H NMR (300 MHz, CDCl3) δ3.80 (2H, m), 3.47 (2H, bs), 3.41 (6H, s), 3.01 (2H, bs).

후처리

  1. filtrationfiltered through celite
  2. concentrationThe filtrate was concentrated, in vacuo
  3. dissolutionre-dissolved in CH2Cl2
  4. dry with materialdried over Na2SO4
  5. concentrationThe solution was concentrated

출처 및 근거

ORD 기록
ord-d4b4edb95fc641c593a69191a2eb1c38
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06869962B2

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