tert-Butyl ((1-benzylpyrrolidin-3-yl)methyl)carbamate → tert-butyl N-((pyrrolidin-3-yl)methyl)carbamate

HRID 985238노트

반응식

HRID 985238 반응식
C([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:9]1)C1C=CC=CC=1>CCOC(C)=O.[OH-].[OH-].[Pd+2]>[NH:8]1[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:19])([CH3:18])[CH3:20])[CH2:9]1

참가 물질

4

반응물 1

HCID 5108694tert-Butyl ((1-benzylpyrrolidin-3-yl)methyl)carbamate

생성물 1

HCID 4250767tert-butyl N-((pyrrolidin-3-yl)methyl)carbamate수율 90.4%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of tert-butyl (1-benzylpyrrolidin-3-yl)methylcarbamate (3.0 g, 10.33 mmole) in EtOAc (100 ml) was added Pd(OH)2 on carbon (0.3 g). The mixture was stirred under H2 balloon at room temperature for 3 h and filtered through Celite. The filtrate was concentrated to give colorless oil (1.87 g, 90%).

후처리

  1. filtrationfiltered through Celite
  2. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-5b6508bd3a614bbc85f84c4c26824186
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06869962B2

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